Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Trientine hydrochloride tnt is chemically known as n22aminoethylaminoethylethane1,2diaminehydrochloride1. Wilsons disease is a condition where the body stores too much copper. There is no advantage in using trientine and penicillamine in combination. This means that searching for aspirin calcium wont return any items that have aspirin glycine calcium because the search term doesnt match exactly. Syprine trientine hydrochloride is used to treat wilsons disease in patients who cannot take the medication known as penicillamine.
It is the metal chelating agent used to bind and remove excess copper in. Identification of the substancemixture and of the companyundertaking 1. When released into the soil, this material may leach into groundwater. Usp currently offers more than 3,500 reference standardshighly characterized specimens of drug substances, excipients, food ingredients, impurities, degradation products, dietary supplements, compendial reagents and performance calibrators.
May 31, 2017 trientine hydrochloride, usp is n,nbis 2aminoethyl1,2ethanediamine dihydrochloride. Thermal stability of bottled vs blister pack containing. No predicted properties have been calculated for this compound. Bis2aminoethyl1,2ethanediamine dihydrochloride, triethylenetetramine dihydrochloride cas number 38260014. Our msds database is an easy to use, do it yourself tool, and best of all. Trientine chelates excess copper cu ions in the body. Activation is not required for the copay card before use. It consists of a polyaminelike structure different from dpenicillamine, as it lack sulfhydryl groups. It is a white to pale yellow crystalline hygroscopic powder. The capsule shell consists of gelatin and titanium dioxide. Searches without any special characters listed below will return items that contain the exact values entered in the search field. This msds has been prepared according to the hazard criteria of the controlled products regulations cpr and the msds contains all of the information required by the cpr. Trientine hydrochloride united states pharmacopeia usp reference standard synonym. This draft guidance, once finalized, will represent the food and drug administrations fdas current thinking on this.
Trientine mobilizes copper ex vivo in human sera, increasing the supernatant percentage in an analytical ultracentrifugation experiment. Trientine hydrochloride is an oral chelator that is structurally unique from other known chelating agents. Capsules syprine contain gelatin, iron oxides, stearic acid, and titanium dioxide as. Mix the combined contents, and transfer an accurately weighed quantity of the powder, equivalent to about 250 mg of trientine hydrochloride, to a 100ml volumetric flask. This oily liquid is colorless but, like many amines, assumes a yellowish color due to impurities resulting from airoxidation. Syprine trientine hydrochloride is available as 250 mg capsules for oral administration. A normalphase highperformance liquid chromatographic assay. Sigmaaldrich offers a number of trientine hydrochloride products. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Niosh manual of analytical methods nmam, fourth edition triethylenetetramine see ethylenedeamine, method 2540, for procedure nh 2 ch 2 ch 2 nhch 2 2 mw. However, we make no warranty of merchantability or any other warranty, express or implied, with. Mar 27, 2017 trientine, chemically known as triethylenetetramine or n,nbis2aminoethyll,2ethanediamine belongs to the class of polyethylene polyamines. Trientine hydrochloride drug entry triethylenetetramine. Trientine is a wellestablished active substance and trientine dihydrochloride 300mg capsules were first licensed in the united kingdom uk in 1985 2.
When released into the soil, this material may evaporate to a moderate extent. Trientine hydrochloride api manufacturers suppliers drug. Clinical experience with syprine is limited and alternate dosing regimens have not been wellcharacterized. Pdf triethylenetetramine teta, a cuiiselective chelator, is commonly used for the treatment of. Buy high quality triethylenetetramine dihydrochloride 38260014 from toronto research chemicals inc. Capsules syprine contain gelatin, iron oxides, stearic acid, and titanium dioxide as inactive ingredients. It does not create or confer any rights for or on any person and does not operate to bind fda or the public. Trientine hydrochloride capsules usp 250 mg are available as 250 mg capsules for oral administration. However, this product offers the advantage of room temperature storage, in comparison to the 300mg capsules which require fridge storage 1,3. Firstline use of trientine dihydrochloride is offlabel. It is freely soluble in water, soluble in methanol, slightly soluble in ethanol, and insoluble in chloroform and ether. Trientine hydrochloride is the hydrochloride salt form of a metal chelating agent with potential antiangiogenic activity.
Syprine trientine hydrochloride dose, indications, adverse. Trientine hydrochloride capsules, usp description n,n. You can use an alternative approach if the approach satisfies. Pdf triethylenetetramine pharmacology and its clinical applications. Trientine hydrochloride, usp is n,nbis 2aminoethyl1,2ethanediamine dihydrochloride. The bioavailability range of oral trientine in fasted rats. Draft guidance on trientine hydrochloride this draft guidance, once finalized, will represent the food and drug administration s fdas current thinking on this topic. View product specific information, msds, references and buying faq. Lithium silicide in contact with hydrogen chloride becomes incandescent. Trientine hydrochloride cas 38260014 cayman chemical. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves. Development and validation of a rapid hplc method for the.
The retrospective observational study by weiss et al. Trientine hydrochloride c6h20cl2n4 cid 71433 structure, chemical names, physical and chemical properties, classification, patents, literature, biological. Linear formula nh 2 ch 2 ch 2 nhch 2 ch 2 2 nh 2 2hcl. The frequencies of both resorptions and fetal abnormalities, including hemorrhage and edema, increased while fetal copper concentrations decreased when trientine hydrochloride was given in the maternal diets of rats. Despite decades of clinical use, knowledge of its pharmacology in human subjects remains incomplete. Trientine hydrochloride monograph for professionals. Handling and storage precautions for safe handling avoid contact with skin and eyes. Rubidium acetylene carbides burns with slightly warm hydrochloric acid. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. As cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 sod1, depletion of copper may inhibit the activation. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020, wolters kluwer updated. Kadmon trientine hydrochloride ndc 6643570010 bottle contains 100 capsule does the patient need to activate the card before using it. Trientine chelates heavy metals including copper, iron, and zinc and forms stable complexes that can be excreted by the kidneys. Trientine dihydrochloride manufactured by univar is available as 300 mg capsules.
Its salt form, trientine triethylenetetramine dihydrochloride or 2,2,2tetramine was introduced in. Sep 09, 2019 provides accurate and independent information on more than 24,000 prescription drugs, overthecounter medicines and natural products. Weigh the contents, and determine the average weight per capsule. Short communication a normalphase highperformance liquid chromatographic assay for aziridine residue in trientine dihydrochloride e. Product identifier product name trientine product number ft37067 cas number 112243 ec number 2039506 1. Ensure personnel are trained on specific chemical hazards present in the lab. Its salt form, trientine triethylenetetramine dihydrochloride or 2,2,2tetramine was introduced in 1969 as an alternative to dpenicillamine. Uranium phosphide reacts with hydrochloric acid to release spontaneously flammable phosphines. Trientine dihydrochloride is a chelating agent which is used to bind and remove copper in the body in the treatment of wilsons disease. Trientine hydrochloride capsules, usp are available as 250 mg capsules for oral administration. Triethylenetetramine teta and trien, also called trientine, is an organic compound with the formula ch 2 nhch 2 ch 2 nh 2 2. Trientine hydrochloride was teratogenic in rats at doses similar to the human dose. Each capsule contains 250 mg trientine hydrochloride, usp and the inactive ingredient stearic acid. Safety data sheet trientine according to regulation ec no 19072006, annex ii, as amended.
Trientine hydrochloride is n,nbis 2aminoethyl1,2ethanediamine dihydrochloride. Trientine hydrochloride is a chelating compound for removal of excess copper from the body. Trientine hydrochloride capsules usp 250 mg contains gelatin, iron oxide black, iron oxide red, iron oxide yellow, potassium hydroxide, propylene glycol. Development and validation of a rapid hplc method for the simultaneous determination of triethylenetetramine and its two main metabolites in human serum. Download msds pdf search msds currently available for download bioworld offers trishcl buffer 1m, ph 8. Sloggemz 1 laboratory of the government chemist, cornwall house, waterloo. Triethylenetetramine teta, a selective cuiichelator used in the treatment of wilsons disease, is now undergoing clinical trials for the treatment of heart failure in diabetes. In patients who cannot tolerate as much as 1 gday initially, initiating dosage with 250 mgday, and increasing gradually to the requisite amount, gives closer control of the effects of the drug and may help to reduce the incidence of adverse reactions. Repeat the acetone addition, trituration, and drying steps. Commission regulation eu no 2015830 of 28 may 2015. As cu is an essential cofactor for cuproenzymes, such as superoxide dismutase 1 sod1, depletion of copper may inhibit the activation of. Trientine hydrochloride capsules, usp 250 mg chelating.
Articles of triethylenetetramine dihydrochloride are included as well. Carbon oxides, nitrogen oxides, hydrogen chloride 5. Dec 22, 2016 trientine hydrochloride is n,nbis 2aminoethyl1,2ethanediamine dihydrochloride. Identification triturate an amount of the contents of capsules, equivalent to about 1. Trientine dihydrochloride api manufacturers suppliers. Syprine trientine hydrochloride capsules, 250 mg, targretin bexarotene capsules, 75 mg, targretin bexarotene gel, 1%. Here, we first used liquid chromatographymass spectrometry lcms to detect and identify major metabolites of. Trientine medicines sps specialist pharmacy service. Triethylenetatramine teta is a highly selective divalent cuii chelator and orphan drug that revereses copper overload in tissues. Safety data sheet according to 29cfr19101200 and ghs rev. Jul 03, 2017 syprine trientine hydrochloride capsules.
Hydrochloric acid, 37% ww safety data sheet according to federal register vol. The chemical structure of trientine hydrochloride is shown in fig1. Trientine hydrochloride united states pharmacopeia usp. Assay dissolve about 220 mg of trientine hydrochloride, accurately weighed, in 150 ml of water in a 250ml beaker. Material may be irritating to the mucous membranes and upper respiratory tract. The adult dosage of trientine dihydrochloride is 12002400 mg 48 capsules daily in 2 to 4 divided doses, preferably 3060 minutes before meals. Calcium carbide reacts with hydrogen chloride gas with incandescence. Maintain material safety data sheets msds for all chemicals.
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